An initiative of eight cooperating institutions, this study will identify the main genetic, lifestyle and psychosocial risk factors for dementia. In addition, the researchers will study brain scans and substances in the blood and brain fluid to find out more about the progress from cognitive health to dementia in order to identify clues for its prevention. The study targets two key causes of dementia: precipitation of the Alzheimer's protein amyloid and damage to blood vessels in the brain.

The study will provide insights into which medication can be used at what point in time to reduce the risk of dementia and/or slow down the development of dementia. The results will also provide a basis for even better recognition and measurement of the first signs of dementia. The results are expected over the next four years.

The parties collaborating on this study are: Amsterdam UMC (VUmc and AMC) (Amsterdam Dementia Cohort, EPAD+, Longitudinal Aging Study Amsterdam), Erasmus MC (Rotterdam Study), LUMC (Leiden Longevity Study), MUMC+ (Maastricht Study), RIVM (Doetinchem Cohort Study), UMCG (Lifelines) and UMC Utrecht (SMART-MR Study). The study is funded by the Netherlands Organisation for Health Research and Development and Alzheimer Nederland.